A iridosquise é a separação dos folhetos da íris, uma condição rara que afeta idosos do sexo feminino, sendo tipicamente bilateral. Este artigo é um relato de caso de facoemulsificação (faco) em uma paciente com iridosquise e catarata branca. Acuidade visual (AV) em decimal com correção ótica (cc) olho esquerdo (OE) apresentava-se 0.001. Foi utilizada a técnica "stop and chop" com quatro afastadores (ganchos) de íris e utilizado lente intraocular (LIO) acrílica dobrável hidrofóbica de três peças sendo introduzida dentro do saco capsular. A paciente evoluiu no pós-operatório (PO) com córnea clara, pressão intraocular (PIO) controlada e estável. Após 30 dias de cirurgia apresentava AV de 1.0 com correção. O implante de ganchos de íris tem papel fundamental no sucesso cirúrgico de pacientes com catarata e iridosquise.

The iridoschisis is the separation of the brochures of the iris. Rare condition that affects typically both eyes of aged woman. The present study is case report of phacoemulsification in patient with iridoschisis and white cataract. Best corrected visual acuity (BCVA) of the left eye was 0.001. The used technique was stop and chop with the use of four hooks of iris and IOL was a folding three pieces hydrophobic acrylic being introduced inside of the capsular bag. Patient evolved in the postoperative with clear cornea , intraocular pressure controlled and steady. After 30 days of surgery he presented BCVA 1.0. The implantation of iris hooks is essential in the surgical success in patient with iridoschisis and cataract.

OBJETIVO: Os antibióticos macrolídeos podem apresentar um efeito antiinflamatório em doenças pulmonares. O objetivo deste estudo é investigar o efeito da claritromicina na resposta inflamatória celular pulmonar em camundongos Swiss. MÉTODO: Foram utilizados 8 camundongos Swiss adultos (6-8 semanas). Todos os animais receberam um desafio intranasal (80 µL) com Pseudomonas aeruginosa mortas (1 x 10(12) UFC/mL). Dois dias após o desafio, foi realizado lavado broncoalveolar (LBA) com contagem total de células (CTC) e exame citológico diferencial. O grupo em estudo (n=4) recebeu tratamento com claritromicina (50mg/kg/dia, intraperitoneal) por 5 dias, sendo iniciado o tratamento 2 dias antes do desafio intranasal. O grupo controle (n=4) não recebeu tratamento com claritromicina. RESULTADOS: Não houve diferença significativa na CTC entre os grupos (média de 2x10(6) e 1,3x10(6), respectivamente). Em ambos os grupos, houve predomínio absoluto de neutrófilos. Contudo, o grupo tratado com claritromicina, apresentou um número percentual significativamente maior de linfócitos no LBA (mediana de 2,5% vs 19%, p=0,029). CONCLUSÃO: O uso de claritromicina altera o exame citológico diferencial do lavado bronco-alveolar de camundongos Swiss com inflamação pulmonar neutrofílica, aumentando significativamente o número percentual de linfócitos.

OBJECTIVE: Macrolide antibiotics have anti-inflammatory properties in lung diseases. The aim of this study was to investigate the effect of clarithromycin in pulmonary cellular inflammatory response in mice. METHOD: Eight adult Swiss mice were studied. All animals received an intranasal challenge (80 µL) with dead Pseudomonas aeruginosa (1.0 x 10(12) CFU/mL). Bronchoalveolar lavage was performed 2 days later, with total cell count and differential cell analysis. The study group (n = 4) received clarithromycin treatment (50 mg/kg/day, intraperitoneal) for 5 days. Treatment was initiated 2 days before intranasal challenge. RESULTS: There was no significant difference in total cell count between the groups (mean: 2.0 x 10(6) and 1.3 x 10(6), respectively). In both groups, there was a predominance of neutrophils. However, the study group had a higher percentage of lymphocytes in the bronchoalveolar lavage than the control group (median of 19% vs 2.5%, P = .029). CONCLUSION: Clarithromycin alters the cytological pattern of bronchoalveolar lavage of Swiss mice with neutrophil pulmonary inflammation, significantly increasing the percentage of lymphocytes.

BACKGROUND: Several lung diseases are characterized by a predominantly neutrophilic inflammation. A better understanding of the mechanisms of action of some drugs on the airway inflammation of such diseases may bring advances to the treatment. OBJECTIVE: To develop a method to induce pulmonary neutrophilic response in mice, without active infection. METHODS: Eight adult Swiss mice were used. The study group (n = 4) received an intranasal challenge with 1 x 10(12) CFU/ml of Pseudomonas aeruginosa (Psa), frozen to death. The control group (n = 4) received an intranasal challenge with saline solution. Two days after the intranasal challenge, a bronchoalveolar lavage (BAL) was performed with total cell and differential cellularity counts. RESULTS: The total cell count was significantly higher in the group with Psa, as compared to the control group (median of 1.17 x 10(6) and 0.08 x 10(6), respectively, p = 0.029). In addition to this, an absolute predominance of neutrophils was found in the differential cellularity of the mice that had received the Psa challenge. CONCLUSIONS: The model of inducing a neutrophilic pulmonary disease using frost-dead bacteria was successfully developed. This neutrophilic inflammatory response induction model in Swiss mice lungs may be an important tool for testing the anti-inflammatory effect of some antimicrobial drugs on the inflammation of the lower airways.